doxycycline in renal failure


Half‐lives and urinary excretion rates of minocycline (MINO) and doxycycline (DOXY) were compared in 8 normal volunteers and in 8 patients with chronic renal failure. Doxycycline has been considered a safe broad-spectrum antibiotic for patients with renal failure. To learn about our use of cookies and how you can manage your cookie settings, please see our Register to receive personalised research and resources by email
Detailed Doxycycline dosage information for adults and children. Please enable it to take advantage of the complete set of features! Doxycycline has been considered a safe broad-spectrum antibiotic for patients with renal failure.


No correlation between serum concentration and degree of renal failure was found. Doxycycline in doses of 200 mg. the first day followed by 100 mg. every 24 hours for 6 days was administered. Magliari F, Mastrangelo F, Lopez T, Rizzelli S, Manisco G, Corliano C.Pediatr Infect Dis J. Includes dosages for Bacterial Infection, Urinary Tract Infection, Acne and more; plus renal, liver and dialysis adjustments. The serum concentration of active drug was measured twice daily, and the urinary drug excretion followed during the study. Review of the literature suggests that occasional patients may have impairment of the nonrenal excretory pathway for doxycycline. Silverchair Information Systems 2007 Feb;26(2):183-5. doi: 10.1097/01.inf.0000250687.05055.67.Drugs. Uncomplicated gonococcal infections in adults (except anorectal infections in men): 100 mg, by mouth, twice a day for 7 days. Each drug was given as a single, 200‐mg intravenous infusion We report here a patient with stable chronic renal failure whose renal function acutely and reversibly deteriorated coincident with a 14-day course of doxycycline. 1979 Nov;18(5):377-91. doi: 10.2165/00003495-197918050-00003. The individual serum levels of doxycycline varied considerably, but there was no tendency to accumulation of active drug in serum. Glomerular filtration rate and effective renal plasma flow, defined as the clearance ofinulin and the clearance of PAH, respectively, were measured before and after the administration period. Download Citation | Doxycycline in renal failure | Twelve patients with grossly impaired renal function were studied.

Studies to date have indicated that administration of doxycycline at the usual recommended doses does not lead to excessive accumulation of the antibiotic in patients with renal impairment. Doxycycline in doses of 200 mg. the first day followed by 100 mg. every 24 hours for 6 days was administered. We speculate that these patients are at risk for developing nephrotoxic levels of this antibiotic. Although doxycycline possesses many of the metabolic properties of the tetracycline group, toxic blood levels usually do not occur because of the drug's unique extrarenal route of excretion. The urinary concentrations of active doxycycline were in the same range as those of the serum. Although doxycycline possesses many of the metabolic properties of the tetracycline group, toxic blood levels usually do not occur because of the drug's unique extrarenal route of excretion. Name must be less than 100 characters Full text Get a printable copy (PDF file) of the complete article (713K), or click on a page image below to browse page by page. The present study supports earlier works claiming that treatment with doxycycline does not lead to deterioration of renal function or drug accumulation, even in advanced renalfailure.We use cookies to improve your website experience.