Select one or more newsletters to continue. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.Copyright 1996-2018 Cerner Multum, Inc. If you take an antacid, take it 1 hour before or 2 hours after you take Nizoral. If you notice other effects not listed above, contact your doctor or pharmacist.Call your doctor for medical advice about side effects. If a patient has been titrated to a stable dosage on buspirone, a dose reduction of buspirone may be necessary to avoid adverse events attributable to buspirone or diminished anxiolytic activity.Calcium channel blockers can have a negative inotropic effect which may be additive to those of ketoconazole. It is, therefore, advisable to monitor digoxin concentrations in patients receiving ketoconazole.Telithromycin: A multiple-dose interaction study with ketoconazole showed that CCilostazol: Concomitant administration of single doses of cilostazol 100 mg and ketoconazole 400 mg approximately doubled cilostazol concentrations and altered (increase/decrease) the concentrations of the active metabolites of cilostazol.Coumarins: Ketoconazole may enhance the anticoagulant effect of coumarin-like drugs, thus the anticoagulant effect should be carefully titrated and monitored.Dabigatran: In patients with moderate renal impairment (CrCL 50 mL/min to ≤ 80 mL/min), consider reducing the dose of dabigatran to 75 mg twice daily when it is coadministered with ketoconazole.Ergot alkaloids: The potential increase in plasma concentrations of ergot alkaloids when coadministered with NizoralEletriptan: Eletriptan should be used with caution with ketoconazole, and specifically, should not be used within at least 72 hours of treatment with ketoconazole.Irinotecan: The potential increase in plasma concentrations of irinotecan when coadministered with NizoralDocetaxel: In the presence of ketoconazole, the clearance of docetaxel in cancer patients was shown to decrease by 50%.Alprazolam, midazolam, triazolam: Coadministration of NizoralPimozide: The potential increase in plasma concentrations of pimozide when coadministered with NizoralAripiprazole: Coadministration of ketoconazole (200 mg/day for 14 days) with a 15 mg single dose of aripiprazole increased the AUC of aripiprazole and its active metabolite by 63% and 77%, respectively. Co-administration of the following drugs with ketoconazole is contraindicated: dofetilide, quinidine, pimozide, cisapride, methadone, disopyramide, dronedarone, ranolazine. You may report side effects to Health Canada at 1-866-234-2345.This medication should be used only if clearly needed during This medicine may be harmful if swallowed. Medications that increase gastric pH or decrease acid output can cause a notable decrease in the bioavailability of ketoconazole. Electronic surveillance presents a … It is not possible to ascertain from the information available whether death was related to ketoconazole therapy or adrenal insufficiency in these patients with serious underlying disease.Anaphylaxis has been reported after the first dose. Some people who were treated with ketoconazole the active ingredient in Nizoralchanges in the electrical activity of your heart called QT prolongation. Inactive ingredients are colloidal silicon dioxide, corn starch, lactose, magnesium stearate, microcrystalline cellulose, and povidone. Disopyramide, dofetilide, dronedarone, quinidine: The potential increase in plasma concentrations of these drugs when coadministered with ketoconazole may increase the risk of serious cardiovascular events including QT prolongation.Digoxin: Rare cases of elevated plasma concentrations of digoxin have been reported.